TLX2

Across TCGA cell cohorts, TLX2 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLX2-associated genes across cancer lineages are IFNG, PTH2, and ASB10. Each is linked with TLX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLX2-to-partner and partner-to-TLX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNG grouped by TLX2-low versus TLX2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX2→partner) and Y-score (partner→TLX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IFNG →	+0.043	+5.321	.003	.005	3	1
CNS	PTH2 →	+0.120	+5.321	<.001	.005	3	1
CNS	ASB10 →	+0.062	+4.981	<.001	.008	3	1
CNS	UCMA →	+0.276	+5.754	<.001	.002	3	1
CNS	OR4D6 →	+0.142	+5.321	<.001	.005	3	1
CNS	OR5A1 →	+1.028	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

IFNG by TLX2 expression — CNS

Explore this box plot interactively →