TLX2

Across TCGA cell cohorts, TLX2 mutation is significantly associated with the mutation status of many other genes, with 2,026 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLX2-associated genes across cancer lineages are ARAP3, SNAPC4, and ATR. Each is linked with TLX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLX2-to-partner and partner-to-TLX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARAP3 grouped by TLX2-low versus TLX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX2→partner) and Y-score (partner→TLX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARAP3 →	+2.392	+3.050	.001	.001	1	3
LARGE_INTESTINE	SNAPC4 →	+2.222	+2.925	.001	.001	1	3
CNS	ATR →	+2.877	+4.360	.006	.006	1	3
BLOOD_Leukemia	FBXO34 →	+6.321	+6.321	.001	.001	1	3
LARGE_INTESTINE	RBM33 →	+2.321	+2.643	.004	.004	1	3
CNS	FBRSL1 →	+4.199	+5.347	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,026 associations by consensus.

ARAP3 by TLX2 expression — LARGE_INTESTINE

Explore this box plot interactively →