TLX1

Across TCGA patient cohorts, TLX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,071 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible TLX1-associated GO terms across cancer lineages are Positive regulation of meiotic cell cycle, Negative regulation of gene expression via chromosomal CpG island methylation, and Regulation of DNA-directed DNA polymerase activity. Each is linked with TLX1 in more than 12 cancer types. Because this analysis shows association rather than direction, both TLX1-to-partner and partner-to-TLX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of meiotic cell cycle grouped by TLX1-low versus TLX1-high in GBM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX1→partner) and Y-score (partner→TLX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	Positive regulation of meiotic cell cycle →	+0.045	+0.758	<.001	<.001	3	13
TGCT	Negative regulation of gene expression via chromosomal CpG island methylation →	+0.074	+1.024	<.001	<.001	3	12
GBM	Regulation of DNA-directed DNA polymerase activity →	+0.052	+0.941	<.001	<.001	2	13
UCS	Positive regulation of ubiquitin protein ligase activity →	+0.060	+1.517	.002	.001	2	13
TGCT	Cellular response to heparin →	+0.181	+1.129	<.001	<.001	3	12
STAD	G2/MI transition of meiotic cell cycle →	+0.056	+0.431	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,071 associations by consensus.

Positive regulation of meiotic cell cycle by TLX1 expression — GBM

Explore this box plot interactively →