TLX1

Across TCGA patient cohorts, TLX1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLX1-associated genes across cancer lineages are A-Raf_pS299, p21, and PKC-a. Each is linked with TLX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLX1-to-partner and partner-to-TLX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TLX1-low versus TLX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX1→partner) and Y-score (partner→TLX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.208	-3.321	<.001	.010	3	1
UCEC	p21 →	+0.224	+2.820	.026	.035	3	1
UCEC	PKC-a →	+0.553	+3.013	.009	.018	3	1
UCEC	BRD4 →	+0.433	+3.010	.003	.019	3	1
UCEC	Chk2_pT68 →	-0.208	-3.321	.033	.010	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

A-Raf_pS299 by TLX1 expression — UCEC

Explore this box plot interactively →