TLR8

Across TCGA pan-cancer cohorts, TLR8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TLR8 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TLR8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TLR8 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

GBM, HNSC, and LSCC are the cancer types where TLR8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.483	0.865	.001	26	view →
HNSC	DFS	Quartile	II,III,IV	0.470	0.839	.012	11	view →
LSCC	DFS	Median	All	1.000	0.597	.006	11	view →
LUAD	OS	Median	III,IV	0.750	0.998	.025	9	view →
PDAC	OS	Median	All	0.712	0.978	.012	2	view →
CCRCC	DFS	Median	All	0.875	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TLR8–GBM (DFS)

Open the GBM breakdown →