Across TCGA pan-cancer cohorts, TLR7 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TLR7 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TLR7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TLR7 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where TLR7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.278	0.438	.035	15	view →
LSCC	DFS	Tertile	III,IV	0.938	0.411	.014	9	view →
LUAD	DFS	Median	All	0.766	0.516	.008	7	view →
UCEC	DFS	Median	All	0.827	1.000	.022	6	view →
CCRCC	OS	Tertile	III,IV	0.490	0.892	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TLR7 tumor-vs-normal RNA expression · all TLR7 data types