Across TCGA patient cohorts, TLR7 protein abundance is significantly associated with the RNA expression of many other genes, with 12,963 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TLR7-associated genes across cancer lineages are FCGR1B, GYPC, and FCGR2A. Each is linked with TLR7 in more than 5 cancer types. Because this analysis shows association rather than direction, both TLR7-to-partner and partner-to-TLR7 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR7→partner) and Y-score (partner→TLR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR1B →	+0.915	+0.555	<.001	<.001	3	6
GBM	GYPC →	+0.841	+0.491	<.001	<.001	3	6
GBM	FCGR2A →	+1.154	+0.584	<.001	<.001	3	6
GBM	CD14 →	+1.393	+0.626	<.001	<.001	3	6
UCEC	CD33 →	+0.984	+0.520	.001	.008	3	5
GBM	LY86 →	+1.190	+0.580	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,963 associations by consensus.

Exploration

TLR7 survival (RNA) · tumor vs normal (RNA) · all TLR7 data types