Across TCGA patient cohorts, TLR7 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR7-associated genes across cancer lineages are ERK2, p62 Lck ligand, and Cyclin-B1. Each is linked with TLR7 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR7-to-partner and partner-to-TLR7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR7→partner) and Y-score (partner→TLR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.160	+1.999	.004	.008	3	3
UCEC	p62 Lck ligand →	+0.395	+3.321	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.586	+1.925	<.001	.004	3	3
UCEC	eEF2 →	+0.393	+2.146	<.001	<.001	3	2
UCEC	FASN →	+0.235	+1.584	.041	.017	3	2
UCEC	FoxM1 →	+0.151	+1.584	.045	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Exploration

TLR7 survival (RNA) · tumor vs normal (RNA) · all TLR7 data types