Across TCGA cell cohorts, TLR7 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,597 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TLR7-associated GO terms across cancer lineages are Positive regulation of hippo signaling, Regulation of synaptic activity, and Positive regulation of transcription elongation by RNA polymerase II. Each is linked with TLR7 in more than 4 cancer types. Because this analysis shows association rather than direction, both TLR7-to-partner and partner-to-TLR7 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR7→partner) and Y-score (partner→TLR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of hippo signaling →	+0.145	+0.023	.001	.006	2	5
BLOOD_Lymphoma	Regulation of synaptic activity →	+0.734	+1.145	.004	.003	3	4
BLOOD_Lymphoma	Positive regulation of transcription elongation by RNA polymerase II →	+0.043	+1.074	.003	.005	3	4
BLOOD_Lymphoma	Regulation of synapse structural plasticity →	-0.868	-1.587	.004	<.001	3	4
BLOOD_Lymphoma	DNA-templated transcription initiation →	+0.042	+1.240	.004	.002	3	4
BLOOD_Lymphoma	NAD+ biosynthetic process →	-0.089	-1.317	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,597 associations by consensus.

Exploration

TLR7 survival (RNA) · tumor vs normal (RNA) · all TLR7 data types