Across TCGA cell cohorts, TLR7 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TLR7-associated genes across cancer lineages are MMP26, GPR171, and CCL18. Each is linked with TLR7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR7-to-partner and partner-to-TLR7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR7→partner) and Y-score (partner→TLR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMP26 →	+0.060	+5.217	<.001	<.001	3	2
LARGE_INTESTINE	GPR171 →	+0.019	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1
LUNG_SCLC	OR13D1 →	+0.043	+4.269	<.001	.005	3	1
SKIN	PAX4 →	+0.016	+2.882	<.001	.005	3	1
SKIN	PPIAL4E →	+0.035	+3.084	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TLR7 survival (RNA) · tumor vs normal (RNA) · all TLR7 data types