TLR6

Across TCGA pan-cancer cohorts, TLR6 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TLR6 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TLR6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TLR6 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, OV, and KIRC are the cancer types where TLR6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.138	0.711	.004	27	view →
OV	OS	Median	II,III,IV	0.285	0.693	.008	18	view →
KIRC	OS	Median	All	0.182	0.805	.003	15	view →
UCEC	DFS	Median	All	0.968	0.608	.005	10	view →
STAD	DFS	Median	All	0.195	0.592	.009	6	view →
SKCM	DFS	Median	All	0.442	0.765	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TLR6–HNSC (OS)

Open the HNSC breakdown →