TLR6

Across TCGA patient cohorts, TLR6 mutation is significantly associated with the RNA expression of many other genes, with 1,826 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR6-associated genes across cancer lineages are REEP4, UFD1, and ESS2. Each is linked with TLR6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR6-to-partner and partner-to-TLR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REEP4 grouped by TLR6-low versus TLR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR6→partner) and Y-score (partner→TLR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	REEP4 →	+0.441	+2.069	.001	<.001	3	3
UCEC	UFD1 →	+0.380	+2.279	<.001	<.001	3	3
UCEC	ESS2 →	+0.251	+3.807	.002	<.001	3	3
UCEC	CINP →	+0.295	+2.354	<.001	<.001	3	3
COAD	HMX3 →	+0.739	+3.541	.007	.005	3	3
UCEC	CYSTM1 →	+0.469	+3.818	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,826 associations by consensus.

REEP4 by TLR6 expression — UCEC

Explore this box plot interactively →