TLR6

Across TCGA patient cohorts, TLR6 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR6-associated genes across cancer lineages are MIG-6, ATM, and RAD51. Each is linked with TLR6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR6-to-partner and partner-to-TLR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by TLR6-low versus TLR6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR6→partner) and Y-score (partner→TLR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.122	+2.866	.024	.033	3	3
UCEC	ATM →	-0.490	-1.662	.002	.011	3	3
COAD	RAD51 →	+0.217	+2.815	.012	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.259	+2.815	.003	.036	3	2
UCEC	EGFR_pY1068 →	-0.278	-2.000	.001	.003	3	2
UCEC	FoxM1 →	+0.201	+2.000	.027	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MIG-6 by TLR6 expression — COAD

Explore this box plot interactively →