TLR6

Across TCGA cell cohorts, TLR6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,139 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TLR6-associated GO terms across cancer lineages are Toll-like receptor TLR6:TLR2 signaling pathway, Detection of bacterial lipopeptide, and Cytoplasmic pattern recognition receptor signaling pathway. Each is linked with TLR6 in more than 15 cancer types. Because this analysis shows association rather than direction, both TLR6-to-partner and partner-to-TLR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Toll-like receptor TLR6:TLR2 signaling pathway grouped by TLR6-low versus TLR6-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR6→partner) and Y-score (partner→TLR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Toll-like receptor TLR6:TLR2 signaling pathway →	-0.285	-1.180	<.001	<.001	2	16
BLOOD_Lymphoma	Detection of bacterial lipopeptide →	+1.625	+2.081	<.001	<.001	3	15
BREAST	Cytoplasmic pattern recognition receptor signaling pathway →	+0.076	+1.919	<.001	<.001	3	12
BONE	Cellular response to abiotic stimulus →	+0.049	+1.291	.001	<.001	3	10
LIVER	Regulation of stress-activated protein kinase signaling cascade →	+0.140	+1.686	<.001	.003	3	10
BONE	Cellular response to environmental stimulus →	+0.049	+1.291	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,139 associations by consensus.

Toll-like receptor TLR6:TLR2 signaling pathway by TLR6 expression — URINARY_TRACT

Explore this box plot interactively →