TLR6

Across TCGA cell cohorts, TLR6 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible TLR6-associated genes across cancer lineages are ARGFX, TAAR8, and CCKAR. Each is linked with TLR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR6-to-partner and partner-to-TLR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARGFX grouped by TLR6-low versus TLR6-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR6→partner) and Y-score (partner→TLR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ARGFX →	+0.106	+5.087	<.001	.004	3	2
BLOOD_Myeloma	TAAR8 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CCKAR →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	GALR1 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	MYL1 →	+0.433	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR7G3 →	+0.886	+4.807	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ARGFX by TLR6 expression — URINARY_TRACT

Explore this box plot interactively →