Across TCGA pan-cancer cohorts, TLR5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TLR5 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TLR5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TLR5 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

GBM, CCRCC, and LSCC are the cancer types where TLR5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.328	0.671	.001	15	view →
CCRCC	DFS	Median	II,III,IV	0.258	0.947	.038	12	view →
LSCC	DFS	Median	All	1.000	0.596	.033	4	view →
LUAD	DFS	Median	III,IV	0.315	0.913	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TLR5 tumor-vs-normal RNA expression · all TLR5 data types