Across TCGA patient cohorts, TLR5 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,078 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TLR5-associated proteins across cancer lineages are BPNT1, NCK1, and EIF4G2. Each is linked with TLR5 in more than 5 cancer types. Because this analysis shows association rather than direction, both TLR5-to-partner and partner-to-TLR5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR5→partner) and Y-score (partner→TLR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BPNT1 →	+0.477	+1.031	<.001	<.001	3	6
OV	NCK1 →	+0.376	+0.859	<.001	<.001	3	6
HNSC	EIF4G2 →	-0.263	-0.585	<.001	.002	3	5
UCEC	IDH1 →	+0.471	+0.699	<.001	<.001	3	5
COAD	DDX21 →	-0.466	-0.581	<.001	<.001	3	5
OV	DDX5 →	-0.288	-0.601	.005	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,078 associations by consensus.

Exploration

TLR5 survival (RNA) · tumor vs normal (RNA) · all TLR5 data types