Across TCGA patient cohorts, TLR5 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR5-associated genes across cancer lineages are ASNS, INPP4B, and ATM. Each is linked with TLR5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR5-to-partner and partner-to-TLR5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR5→partner) and Y-score (partner→TLR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.765	+2.815	<.001	.036	3	3
UCEC	INPP4B →	-0.227	-1.765	.028	.011	3	3
UCEC	ATM →	-0.581	-2.986	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.706	+2.189	<.001	.001	3	3
STAD	beta-Catenin →	+0.790	+3.000	.035	.036	3	2
SKCM	Rad50 →	-0.208	-1.665	.027	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration

TLR5 survival (RNA) · tumor vs normal (RNA) · all TLR5 data types