Across TCGA cell cohorts, TLR5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,652 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TLR5-associated GO terms across cancer lineages are Negative regulation of complement activation, alternative pathway, Proteasomal ubiquitin-independent protein catabolic process, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with TLR5 in more than 15 cancer types. Because this analysis shows association rather than direction, both TLR5-to-partner and partner-to-TLR5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR5→partner) and Y-score (partner→TLR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of complement activation, alternative pathway →	+1.432	+1.741	.003	<.001	3	16
PANCREAS	Proteasomal ubiquitin-independent protein catabolic process →	+0.104	+1.053	<.001	<.001	3	11
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.085	+0.606	.001	.004	3	10
LARGE_INTESTINE	COPII-coated vesicle budding →	+0.077	+0.595	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Autophagosome assembly →	+0.057	+1.113	.007	.004	2	11
BLOOD_Lymphoma	Response to topologically incorrect protein →	+0.065	+0.384	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,652 associations by consensus.

Exploration

TLR5 survival (RNA) · tumor vs normal (RNA) · all TLR5 data types