TLR3

Across TCGA pan-cancer cohorts, TLR3 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TLR3 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher TLR3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TLR3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LGG show a favorable association.

THYM, DLBC, and UCEC are the cancer types where TLR3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
UCEC	DFS	Median	All	0.975	0.826	.009	28	view →
STAD	OS	Median	II,III,IV	0.235	0.716	.004	12	view →
COAD	OS	Median	All	0.168	0.799	.004	12	view →
LUAD	OS	Median	II,III,IV	0.237	0.709	.043	3	view →
LGG	OS	Median	All	1.000	0.420	.020	1	view →
SKCM	DFS	Median	III,IV	0.814	0.464	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TLR3–THYM (OS)

Open the THYM breakdown →