TLR3

Across TCGA pan-cancer cohorts, TLR3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TLR3 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TLR3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TLR3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where TLR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.979	0.163	.003	52	view →
PDAC	DFS	Median	All	0.664	0.835	.001	51	view →
LSCC	OS	Median	II,III,IV	0.630	0.920	<.001	12	view →
GBM	DFS	Median	All	0.276	0.462	.005	9	view →
HNSC	OS	Tertile	All	0.947	0.827	.027	5	view →
UCEC	OS	Tertile	All	1.000	0.929	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TLR3–CCRCC (DFS)

Open the CCRCC breakdown →