TLR3

Across TCGA patient cohorts, TLR3 RNA expression is significantly associated with the RNA expression of many other genes, with 19,265 significant associations in total. UVM shows the largest number of these associations.

The most reproducible TLR3-associated genes across cancer lineages are CTSO, CMPK2, and PARP14. Each is linked with TLR3 in more than 33 cancer types. Because this analysis shows association rather than direction, both TLR3-to-partner and partner-to-TLR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TLR3 versus CTSO in ACC, with a Pearson correlation of 0.78.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR3→partner) and Y-score (partner→TLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	CTSO →	+1.565	+1.165	<.001	<.001	3	34
HNSC	CMPK2 →	+1.483	+1.047	<.001	<.001	3	34
UVM	PARP14 →	+1.512	+1.070	<.001	<.001	3	33
SCLC	SAMD9 →	+2.213	+1.367	<.001	<.001	3	33
SCLC	TRIM56 →	+1.279	+0.913	<.001	.001	3	33
UCS	DDX58 →	+1.662	+1.524	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,265 associations by consensus.

TLR3 vs CTSO — ACC

Explore this scatter interactively →