TLR3

Across TCGA patient cohorts, TLR3 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,089 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TLR3-associated proteins across cancer lineages are PSMB10, DDX60, and TRIM21. Each is linked with TLR3 in more than 8 cancer types. Because this analysis shows association rather than direction, both TLR3-to-partner and partner-to-TLR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TLR3 versus PSMB10 in HNSC, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR3→partner) and Y-score (partner→TLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PSMB10 →	+0.647	+0.775	<.001	<.001	3	9
HNSC	DDX60 →	+0.664	+0.697	<.001	<.001	3	8
HNSC	TRIM21 →	+0.641	+1.057	<.001	<.001	3	7
HNSC	TRIM22 →	+0.615	+0.606	<.001	<.001	3	7
HNSC	UBA7 →	+0.534	+0.938	<.001	<.001	3	7
GBM	FAS →	+0.654	+0.512	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,089 associations by consensus.

TLR3 vs PSMB10 — HNSC

Explore this scatter interactively →