TLR3

Across TCGA patient cohorts, TLR3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,995 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TLR3-associated genes across cancer lineages are CTSO, RTP4, and SERPING1. Each is linked with TLR3 in more than 7 cancer types. Because this analysis shows association rather than direction, both TLR3-to-partner and partner-to-TLR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TLR3 versus CTSO in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR3→partner) and Y-score (partner→TLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CTSO →	+0.700	+0.438	<.001	<.001	3	8
OV	RTP4 →	+1.377	+0.624	.001	<.001	3	7
BRCA	SERPING1 →	+0.910	+0.307	<.001	.001	3	6
LSCC	UBA7 →	+0.848	+0.589	<.001	<.001	3	6
HNSC	GBP3 →	+1.051	+0.391	<.001	.002	3	6
OV	SLC15A3 →	+0.921	+0.378	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,995 associations by consensus.

TLR3 vs CTSO — BRCA

Explore this scatter interactively →