TLR3

Across TCGA patient cohorts, TLR3 protein abundance is significantly associated with the protein abundance of many other proteins, with 19,198 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TLR3-associated proteins across cancer lineages are UNC93B1, ACTL6A, and CD63. Each is linked with TLR3 in more than 7 cancer types. Because this analysis shows association rather than direction, both TLR3-to-partner and partner-to-TLR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TLR3 versus UNC93B1 in PDAC, with a Pearson correlation of 0.55.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR3→partner) and Y-score (partner→TLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	UNC93B1 →	+0.677	+0.341	<.001	<.001	3	8
LSCC	ACTL6A →	-0.307	-0.377	<.001	.002	3	7
OV	CD63 →	+0.765	+0.467	<.001	.002	3	7
LSCC	PUS7 →	-0.548	-0.513	<.001	<.001	3	7
BRCA	SYNCRIP →	-0.293	-0.541	.001	<.001	2	8
GBM	LSM14B →	-0.443	-0.422	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,198 associations by consensus.

TLR3 vs UNC93B1 — PDAC

Explore this scatter interactively →