TLR3

Across TCGA patient cohorts, TLR3 mutation is significantly associated with the RNA expression of many other genes, with 2,681 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR3-associated genes across cancer lineages are MIR6737, SCN4B, and OR6M1. Each is linked with TLR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR3-to-partner and partner-to-TLR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6737 grouped by TLR3-low versus TLR3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR3→partner) and Y-score (partner→TLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6737 →	+0.388	+4.506	<.001	.009	3	3
UCEC	SCN4B →	-0.351	-2.076	.004	.005	3	3
CESC	OR6M1 →	+0.056	+5.418	<.001	.005	3	2
READ	ASNSP6 →	+0.037	+5.925	.007	.002	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2
READ	MIR6744 →	+1.707	+5.925	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,681 associations by consensus.

MIR6737 by TLR3 expression — BRCA

Explore this box plot interactively →