TLR3

Across TCGA patient cohorts, TLR3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR3-associated genes across cancer lineages are c-Met_pY1235, PCNA, and JNK2. Each is linked with TLR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TLR3-to-partner and partner-to-TLR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by TLR3-low versus TLR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR3→partner) and Y-score (partner→TLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.069	+2.137	.006	.001	3	4
UCEC	PCNA →	+0.206	+2.700	.005	.005	3	3
SKCM	JNK2 →	-0.231	-1.683	.007	.043	3	3
UCEC	eIF4E →	+0.156	+3.335	.030	.005	3	2
UCEC	p27_pT198 →	+0.082	+2.321	.024	.005	3	2
UCEC	Shc_pY317 →	-0.112	-1.678	.030	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

c-Met_pY1235 by TLR3 expression — UCEC

Explore this box plot interactively →