TLR3

Across TCGA cell cohorts, TLR3 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLR3-associated genes across cancer lineages are ADRA1A, KRT85, and CCDC42. Each is linked with TLR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR3-to-partner and partner-to-TLR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRA1A grouped by TLR3-low versus TLR3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR3→partner) and Y-score (partner→TLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADRA1A →	+0.146	+3.688	.001	.002	3	1
LARGE_INTESTINE	KRT85 →	+0.430	+3.453	<.001	.009	3	1
LARGE_INTESTINE	CCDC42 →	+0.045	+3.510	<.001	.003	3	1
LARGE_INTESTINE	TLX3 →	+0.390	+3.845	.007	.003	3	1
LARGE_INTESTINE	SERPINB12 →	+0.110	+3.823	<.001	.006	3	1
LARGE_INTESTINE	HTR1E →	+0.070	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ADRA1A by TLR3 expression — LARGE_INTESTINE

Explore this box plot interactively →