TLR2

Across TCGA patient cohorts, TLR2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR2-associated genes across cancer lineages are TFRC, HER2_pY1248, and S6_pS240_S244. Each is linked with TLR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR2-to-partner and partner-to-TLR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by TLR2-low versus TLR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR2→partner) and Y-score (partner→TLR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.563	+2.137	.001	.001	3	3
SKCM	HER2_pY1248 →	-0.129	-2.807	.042	.003	3	2
SKCM	S6_pS240_S244 →	+0.486	+2.186	.007	.032	3	2
SKCM	CDK1 →	+0.240	+2.115	.001	.018	3	2
UCEC	Cyclin-B1 →	+0.692	+1.807	<.001	.004	3	2
UCEC	A-Raf_pS299 →	-0.122	-2.321	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

TFRC by TLR2 expression — UCEC

Explore this box plot interactively →