TLR2

Across TCGA cell cohorts, TLR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,829 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TLR2-associated GO terms across cancer lineages are Microglia development, Positive regulation of matrix metallopeptidase secretion, and Positive regulation of interleukin-18 production. Each is linked with TLR2 in more than 16 cancer types. Because this analysis shows association rather than direction, both TLR2-to-partner and partner-to-TLR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microglia development grouped by TLR2-low versus TLR2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR2→partner) and Y-score (partner→TLR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Microglia development →	-0.305	-1.936	<.001	<.001	3	17
URINARY_TRACT	Positive regulation of matrix metallopeptidase secretion →	-0.328	-1.789	<.001	.001	2	17
PANCREAS	Positive regulation of interleukin-18 production →	-0.300	-1.328	<.001	.001	3	16
PANCREAS	Regulation of interleukin-18 production →	-0.342	-1.379	<.001	.001	3	14
LIVER	Regulation of response to macrophage colony-stimulating factor →	-0.318	-1.192	<.001	.008	3	11
LIVER	Regulation of cellular response to macrophage colony-stimulating factor stimulus →	-0.318	-1.192	<.001	.008	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,829 associations by consensus.

Microglia development by TLR2 expression — OESOPHAGUS

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