TLR2

Across TCGA cell cohorts, TLR2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLR2-associated genes across cancer lineages are ZAN, C1orf87, and IFNA2. Each is linked with TLR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR2-to-partner and partner-to-TLR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by TLR2-low versus TLR2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR2→partner) and Y-score (partner→TLR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZAN →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	C1orf87 →	+0.055	+5.000	<.001	.006	3	1
PANCREAS	IFNA2 →	+0.016	+5.000	<.001	.006	3	1
BREAST	KRTAP4-12 →	+0.046	+5.781	<.001	.001	3	1
BLOOD_Leukemia	BPIFB6 →	+0.037	+4.384	<.001	.006	3	1
BLOOD_Leukemia	FREM3 →	+0.122	+3.860	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ZAN by TLR2 expression — PANCREAS

Explore this box plot interactively →