TLR1

Across TCGA pan-cancer cohorts, TLR1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TLR1 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TLR1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TLR1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, LUAD, and CCRCC are the cancer types where TLR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.690	0.498	.018	9	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.777	.018	9	view →
CCRCC	DFS	Median	All	1.000	0.392	.022	4	view →
LSCC	DFS	Median	III,IV	0.990	0.514	.005	4	view →
HNSC	DFS	Median	IV	0.497	0.921	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TLR1–GBM (OS)

Open the GBM breakdown →