TLR1

Across TCGA patient cohorts, TLR1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR1-associated genes across cancer lineages are eIF4E, PCNA, and Caspase-7-cleavedD198. Each is linked with TLR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR1-to-partner and partner-to-TLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TLR1-low versus TLR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR1→partner) and Y-score (partner→TLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.157	+1.459	.021	.012	3	3
UCEC	PCNA →	+0.198	+1.459	.004	.012	3	3
UCEC	Caspase-7-cleavedD198 →	+0.488	+2.019	.011	.005	3	3
UCEC	c-Met_pY1235 →	+0.054	+1.459	.025	.012	3	3
UCEC	Cyclin-B1 →	+0.769	+2.000	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.263	-2.502	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

eIF4E by TLR1 expression — UCEC

Explore this box plot interactively →