TLR1

Across TCGA cell cohorts, TLR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,277 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TLR1-associated GO terms across cancer lineages are Detection of bacterial lipopeptide, Response to triacyl bacterial lipopeptide, and Cellular response to triacyl bacterial lipopeptide. Each is linked with TLR1 in more than 12 cancer types. Because this analysis shows association rather than direction, both TLR1-to-partner and partner-to-TLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Detection of bacterial lipopeptide grouped by TLR1-low versus TLR1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR1→partner) and Y-score (partner→TLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Detection of bacterial lipopeptide →	+1.384	+2.009	<.001	<.001	3	13
BLOOD_Lymphoma	Response to triacyl bacterial lipopeptide →	+1.231	+1.902	<.001	<.001	3	11
BLOOD_Lymphoma	Cellular response to triacyl bacterial lipopeptide →	+1.231	+1.902	<.001	<.001	3	11
URINARY_TRACT	Toll-like receptor TLR6:TLR2 signaling pathway →	-0.193	-0.368	.001	.009	2	12
LUNG_SCLC	Xenophagy →	+0.167	+0.616	<.001	<.001	3	10
BLOOD_Lymphoma	Detection of bacterial lipoprotein →	+1.367	+1.932	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,277 associations by consensus.

Detection of bacterial lipopeptide by TLR1 expression — BLOOD_Lymphoma

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