TLR1

Across TCGA cell cohorts, TLR1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TLR1-associated genes across cancer lineages are PRR23C, NUPR2, and ZCCHC13. Each is linked with TLR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR1-to-partner and partner-to-TLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23C grouped by TLR1-low versus TLR1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR1→partner) and Y-score (partner→TLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRR23C →	+0.009	+3.990	<.001	.003	3	2
BLOOD_Leukemia	NUPR2 →	+0.073	+4.539	<.001	.007	3	1
BLOOD_Leukemia	ZCCHC13 →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	KRTAP4-11 →	+0.016	+4.539	<.001	.007	3	1
BLOOD_Leukemia	GRXCR1 →	+0.017	+5.569	<.001	.001	3	1
BLOOD_Leukemia	SPATA31A7 →	+0.028	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PRR23C by TLR1 expression — OVARY

Explore this box plot interactively →