TLN1

Across TCGA patient cohorts, TLN1 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLN1-associated genes across cancer lineages are eIF4E, INPP4B, and 4E-BP1_pT37_T46. Each is linked with TLN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TLN1-to-partner and partner-to-TLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TLN1-low versus TLN1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLN1→partner) and Y-score (partner→TLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	eIF4E →	+0.177	+2.331	.009	.019	3	5
UCEC	INPP4B →	-0.239	-1.807	.005	.003	3	4
UCEC	4E-BP1_pT37_T46 →	-0.295	-1.379	.003	.015	3	4
COAD	PDCD4 →	-0.495	-2.450	.006	.020	3	3
LUSC	PI3K-p85 →	+0.170	+3.013	.017	.018	2	4
LUSC	Shc_pY317 →	-0.231	-3.413	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

eIF4E by TLN1 expression — LUSC

Explore this box plot interactively →