TLN1

Across TCGA cell cohorts, TLN1 mutation is significantly associated with the RNA expression of many other genes, with 845 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLN1-associated genes across cancer lineages are PLA2G2F, OR6V1, and IQCF5. Each is linked with TLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLN1-to-partner and partner-to-TLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G2F grouped by TLN1-low versus TLN1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLN1→partner) and Y-score (partner→TLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PLA2G2F →	+0.175	+4.222	<.001	.007	3	2
LUNG_SCLC	OR6V1 →	+0.034	+3.817	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	2
BLOOD_Leukemia	MED31 →	+0.515	+3.115	.001	.009	3	2
BLOOD_Leukemia	C12orf57 →	+1.033	+2.505	<.001	.005	3	2
BLOOD_Leukemia	GPR63 →	+0.960	+3.285	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 845 associations by consensus.

PLA2G2F by TLN1 expression — SOFT_TISSUE

Explore this box plot interactively →