TLL1

Across TCGA patient cohorts, TLL1 mutation is significantly associated with the RNA expression of many other genes, with 7,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLL1-associated genes across cancer lineages are TIMM44, DDX55, and WDR43. Each is linked with TLL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TLL1-to-partner and partner-to-TLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM44 grouped by TLL1-low versus TLL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLL1→partner) and Y-score (partner→TLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM44 →	+0.352	+1.617	<.001	<.001	3	5
LUAD	DDX55 →	+0.459	+3.759	<.001	<.001	3	5
LUAD	WDR43 →	+0.552	+2.404	<.001	<.001	3	5
UCEC	GATAD2A →	+0.291	+1.462	.002	<.001	3	5
LUAD	TIMM23 →	+0.260	+2.321	.007	.006	3	4
UCEC	SKA1 →	+0.719	+1.908	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,668 associations by consensus.

TIMM44 by TLL1 expression — UCEC

Explore this box plot interactively →