TLK2

Across TCGA pan-cancer cohorts, TLK2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TLK2 data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TLK2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TLK2 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

HNSC, LSCC, and GBM are the cancer types where TLK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.436	0.821	<.001	58	view →
LSCC	DFS	Quartile	All	0.207	0.853	.010	4	view →
GBM	DFS	Median	All	0.448	0.295	.018	4	view →
CCRCC	OS	Median	III,IV	1.000	0.353	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TLK2–HNSC (DFS)

Open the HNSC breakdown →