TLK2

Across TCGA patient cohorts, TLK2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,018 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TLK2-associated genes across cancer lineages are INTS2, TRIM37, and BIRC5. Each is linked with TLK2 in more than 6 cancer types. Because this analysis shows association rather than direction, both TLK2-to-partner and partner-to-TLK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TLK2 versus INTS2 in HNSC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK2→partner) and Y-score (partner→TLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	INTS2 →	+0.690	+0.350	<.001	<.001	3	7
HNSC	TRIM37 →	+0.748	+0.246	.007	.004	3	6
UCEC	BIRC5 →	+1.044	+0.190	.001	.001	3	6
LSCC	NOL11 →	+0.763	+0.257	<.001	<.001	3	6
BRCA	CEP95 →	+0.534	+0.455	.005	<.001	3	6
UCEC	RAD51AP1 →	+1.001	+0.270	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,018 associations by consensus.

TLK2 vs INTS2 — HNSC

Explore this scatter interactively →