TLK2

Across TCGA patient cohorts, TLK2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLK2-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with TLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLK2-to-partner and partner-to-TLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TLK2-low versus TLK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK2→partner) and Y-score (partner→TLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.723	-3.794	<.001	<.001	3	2
SKCM	Caspase-7-cleavedD198 →	+0.635	+3.169	.044	.019	3	2
UCEC	Cyclin-B1 →	+0.778	+2.392	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.126	-2.973	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.246	-1.662	.005	.011	3	1
UCEC	eIF4G →	+0.279	+3.169	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ATM by TLK2 expression — UCEC

Explore this box plot interactively →