TLK2

Across TCGA cell cohorts, TLK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,112 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TLK2-associated GO terms across cancer lineages are Heterochromatin organization, Heterochromatin formation, and Negative regulation of gene expression, epigenetic. Each is linked with TLK2 in more than 17 cancer types. Because this analysis shows association rather than direction, both TLK2-to-partner and partner-to-TLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin organization grouped by TLK2-low versus TLK2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK2→partner) and Y-score (partner→TLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Heterochromatin organization →	+0.101	+0.664	<.001	.001	3	18
BONE	Heterochromatin formation →	+0.103	+0.706	<.001	<.001	3	17
BONE	Negative regulation of gene expression, epigenetic →	+0.104	+0.798	<.001	<.001	3	17
SOFT_TISSUE	Protein-DNA complex organization →	+0.074	+0.809	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.071	+0.967	<.001	<.001	2	17
LARGE_INTESTINE	Positive regulation of mRNA metabolic process →	+0.067	+0.741	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,112 associations by consensus.

Heterochromatin organization by TLK2 expression — BONE

Explore this box plot interactively →