TLK2

Across TCGA cell cohorts, TLK2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TLK2-associated genes across cancer lineages are GLB1L3, TBX5, and ST6GAL2. Each is linked with TLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLK2-to-partner and partner-to-TLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLB1L3 grouped by TLK2-low versus TLK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK2→partner) and Y-score (partner→TLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GLB1L3 →	+0.613	+3.716	<.001	.003	3	1
LARGE_INTESTINE	TBX5 →	+0.218	+3.626	.002	.006	3	1
BLOOD_Lymphoma	ST6GAL2 →	+0.679	+4.058	<.001	.003	3	1
BLOOD_Lymphoma	SLC38A8 →	+0.075	+3.606	<.001	.002	3	1
BLOOD_Lymphoma	OR9K2 →	+0.011	+4.247	<.001	.004	3	1
BLOOD_Lymphoma	CEACAM3 →	+0.060	+3.342	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GLB1L3 by TLK2 expression — LARGE_INTESTINE

Explore this box plot interactively →