Across TCGA pan-cancer cohorts, TLK1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TLK1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TLK1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TLK1 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

LSCC, LUAD, and COAD are the cancer types where TLK1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TLK1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.559	<.001	9	view →
LUAD	Male	All	+0.371	<.001	9	view →
COAD	Male	All	−0.770	.003	5	view →
HNSC	Male	IV	+0.397	<.001	4	view →
PDAC	All	All	−0.224	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TLK1 RNA expression & survival · all TLK1 data types