Across TCGA patient cohorts, TLK1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,107 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TLK1-associated genes across cancer lineages are METTL8, HAT1, and NUP35. Each is linked with TLK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TLK1-to-partner and partner-to-TLK1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK1→partner) and Y-score (partner→TLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	METTL8 →	+0.476	+0.277	<.001	<.001	3	6
LSCC	HAT1 →	+0.443	+0.248	<.001	<.001	3	5
OV	NUP35 →	+0.575	+0.358	<.001	<.001	3	5
LSCC	WDR43 →	+0.598	+0.267	<.001	<.001	3	5
GBM	LIN9 →	+0.620	+0.293	<.001	<.001	3	5
UCEC	NCAPH →	+0.846	+0.216	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,107 associations by consensus.

Exploration

TLK1 survival (RNA) · tumor vs normal (RNA) · all TLK1 data types