TLK1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TLK1 mutation is significantly associated with the RNA expression of many other genes, with 5,117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLK1-associated genes across cancer lineages are RNA5SP155, PCBP2P1, and TLE6. Each is linked with TLK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLK1-to-partner and partner-to-TLK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK1→partner) and Y-score (partner→TLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRNA5SP155 →+0.317+1.334<.001.00133
COADPCBP2P1 →+0.388+3.375<.001.00533
UCECTLE6 →+0.490+1.365.002.00133
SKCMRCCD1-AS1 →+0.444+3.265<.001.00832
UCECYTHDF3-AS1 →+0.585+1.668<.001.00132
UCECNOL12 →+0.291+2.424<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 5,117 associations by consensus.

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