Across TCGA patient cohorts, TLK1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLK1-associated genes across cancer lineages are GAPDH, INPP4B, and mTOR_pS2448. Each is linked with TLK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLK1-to-partner and partner-to-TLK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK1→partner) and Y-score (partner→TLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.692	+2.820	.005	.035	3	3
COAD	INPP4B →	-0.610	-3.000	<.001	.034	3	3
UCEC	mTOR_pS2448 →	-0.120	-1.787	.007	.003	3	3
COAD	ASNS →	+0.697	+3.178	<.001	.010	3	3
COAD	ATM →	-0.718	-3.000	<.001	.034	3	3
UCEC	CDK1 →	+0.107	+1.335	.017	.040	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Exploration

TLK1 survival (RNA) · tumor vs normal (RNA) · all TLK1 data types