Across TCGA cell cohorts, TLK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,842 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TLK1-associated GO terms across cancer lineages are Sex-chromosome dosage compensation, Negative regulation of gene expression, epigenetic, and Peptidyl-serine phosphorylation. Each is linked with TLK1 in more than 14 cancer types. Because this analysis shows association rather than direction, both TLK1-to-partner and partner-to-TLK1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK1→partner) and Y-score (partner→TLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Sex-chromosome dosage compensation →	+0.124	+0.835	.001	.004	3	15
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.089	+1.024	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Peptidyl-serine phosphorylation →	+0.094	+0.798	<.001	.002	3	14
LARGE_INTESTINE	Heterochromatin organization →	+0.070	+0.755	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Peptidyl-serine modification →	+0.090	+0.829	<.001	<.001	3	13
SOFT_TISSUE	Late viral transcription →	+0.124	+0.515	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,842 associations by consensus.

Exploration

TLK1 survival (RNA) · tumor vs normal (RNA) · all TLK1 data types