Across TCGA cell cohorts, TLK1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLK1-associated genes across cancer lineages are FSHB, FAM153B, and TAFA1. Each is linked with TLK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLK1-to-partner and partner-to-TLK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK1→partner) and Y-score (partner→TLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FSHB →	+0.016	+6.247	<.001	<.001	3	1
LARGE_INTESTINE	FAM153B →	+0.494	+3.618	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	TKTL2 →	+0.045	+3.187	<.001	.006	2	1
LARGE_INTESTINE	SMIM33 →	+0.785	+3.426	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

TLK1 survival (RNA) · tumor vs normal (RNA) · all TLK1 data types