TLE4

Across TCGA patient cohorts, TLE4 protein abundance is significantly associated with the RNA expression of many other genes, with 5,105 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TLE4-associated genes across cancer lineages are PPFIBP2, SIPA1L2, and TMEM154. Each is linked with TLE4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLE4-to-partner and partner-to-TLE4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TLE4 versus PPFIBP2 in PDAC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE4→partner) and Y-score (partner→TLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPFIBP2 →	+0.681	+0.422	.003	.002	3	3
LUAD	SIPA1L2 →	+0.705	+0.260	.004	.001	3	3
LSCC	TMEM154 →	+0.790	+0.381	.001	<.001	3	3
PDAC	AKNA →	+0.719	+0.408	.004	.005	3	3
PDAC	CEROX1 →	+1.104	+0.476	<.001	.001	3	3
UCEC	MIR548AX →	+1.605	+0.611	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,105 associations by consensus.

TLE4 vs PPFIBP2 — PDAC

Explore this scatter interactively →